TLR4 Variation in Yellowstone Bison

Submitted by bsiadmin on Mon, 04/07/2008 - 16:59.

Publication Type:

Journal Article

Authors:

White, S. N.; Halbert, Natalie D.; Taylor, K. H.; Derr, James N.; Womack, J. E.

Source:

Animal Genetics, Volume 36, p.511-542 (2005)

Keywords:

bison; genetics; immunity; Brucella; Mycobacteria; Pasteurella; pathogens; Salmonella; TLR4; tuberculosis; wildlife health; Mycobacterium bovis; brucella abortus; bacteria

Abstract:

Toll-like receptor 4 (TLR4) is a cell-surface receptor that activates innate and adaptive immune responses. Because it recognizes a broad class of pathogen associated molecular patterns, including lipopolysaccharides, TLR4 is a candidate gene for resistance to a large number of pathogens. Important examples are Gramnegative Salmonella,1 Pasteurella,2, and Brucella, as well as Mycobacteria,3 which include the causative agents of tuberculosis and Johne’s disease.

Notes:

Found in Bison Library, pdf on computerNatureBib ID: 652406